Chronic heart failure Circulatory System Other rheumatic heart diseases
Conditions
Interventions
Every patient will have a total of 4 visits.
Preliminary visit:
For explaining the nature of the trial, get the consent forms signed and for demonstration of SphygmoCardiography technique and to ge
haematological and biochemical screening. Baseline echocardiogram and ECG will also be done.
Visit 0:
For arterial stiffness parameters measurements and baseline stress test, after which the patient
Sponsors
Imam Abdulrahman bin Faisal University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged greater than 18 years, either sex 2. Chronic heart failure patients with functional class II - III (according to New York Heart Association [NYHA]) 3. Clinical stabilisation of cardiac condition and medications for at least 3 months prior to involvement
Exclusion criteria
Exclusion criteria: 1. Serum creatinine greater than 2 mg/dl or creatinine clearance of less than 60 ml/min 2. Recent admission to hospital within the last 3 months due to decompensated heart failure or new ischaemic event 3. Uncontrolled blood pressure (BP greater than 160/100 mmHg) 4. Concomitant antioxidant vitamins 5. Known hypersensitivity reaction to allopurinol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial stiffness indices: 1. Pulse wave velocity (PWV) 2. Augmentation index Assessed at visit 0 (baseline) and after 90 days post-randomisation (visit 1) | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise capacity, assessed at visit 0 (baseline) and after 90 days post-randomisation (visit 1) | — |
Countries
Saudi Arabia
Outcome results
None listed