Colorectal cancer Cancer Colorectal cancer
Conditions
Interventions
Intervention: detection of faecal blood by Haemoccult analyses of samples from three consecutive stools, in the group randomised to "screening"
Control: no contact/information
If blood was detected,
Sponsors
Swedish Cancer Society (Sweden)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The entire population was born between 1918 and 1931, men and women, in Goteborg, Sweden. Only those randomised to "intervention, i.e., screening for occult faecal blood" were invited to participate, the control group was not contacted. Initial invitation to the trial was when each individual was between the ages of 60 to 64 years, thus inclusion from 1982 to 1995 in cohorts of five years.
Exclusion criteria
Exclusion criteria: Does not meet the above criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality in colorectal cancer. Time points were: after invitation, after screening participation, after work-up of positive screen test and after treatment for patients with positive work-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Overall mortality 2. Quality of life 3. Sensitivity and specificity of screening procedure 4. Sensitivity and specificity of work up procedure 5. Stage distribution of adenomas and cancers The questionnaires used were specifically designed for this trial, with face validation and tested in pilot populations before use. Time points were: after invitation, after screening participation, after work-up of positive screen test and after treatment for patients with positive work-up. | — |
Countries
Sweden
Outcome results
None listed