Multivessel coronary artery disease Circulatory System Cronary artery disease
Conditions
Interventions
Patients undergo coronary artery bypass grafting with internal mammary artery, radial or saphenous vein in the two groups using the same anaesthetic protocol, the same graft anastomotic techniques and
Sponsors
Hospital da Cruz Vermelha (Portugal)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients between 30 and 90 years 2. Multivessel disease 3. Indication for primary coronary artery bypass graft (CABG) for at least three distal anastomoses according to consensus given by two independent surgeons
Exclusion criteria
Exclusion criteria: 1. Patient requiring emergency surgery such as: 1.1. Ventilatory support 1.2. Intravenous inotropic therapy 1.3. Cardiogenic shock 1.4. Catheterism accident 1.5. Q-wave myocardial infarction in evolution 2. Need for associated procedures 3. Renal insufficiency or serum creatinine 1.5 times superior to the upper limit normal values 4. Atrial fibrillation 5. Known allergy to contrast material 6. Dyspnoea at rest or inability to hold breath 7. Women with child bearing potential (for the purpose of this study women which have menopause for less than 12 months will be excluded, with exception for those with surgical menopause) 8. Inability to give inform consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Graft patency at 4 - 6 weeks evaluated by 16 slice computed tomography. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Post-operative adverse events 2. Neurocognitive testing at baseline and 4 - 6 weeks 3. Quality of life at baseline and 6 months 4. Adverse events and stress test at 6 months | — |
Countries
Portugal
Outcome results
None listed