Periodontitis Oral Health
Conditions
Interventions
This research will be a randomized (clinical) controlled trial (RCT) to compare the effectiveness of Triple Antibiotic Paste (TAP) as adjunctive with a control group receiving conventional periodontal
which is scaling and root surface debridement.
Patients will be randomly allocated into two groups: one receiving Triple Antibiotic Paste (TAP) and the other receiving conventional periodontal ther
Sponsors
Universiti Teknologi MARA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Systematically healthy adult patients diagnosed with Chronic Periodontitis Stage III and IV Grade A/B/C, aged between 30-65 years old 2. Patient with deep periodontal pocket, at least two quadrants with pocket >5 mm 3. Patients who have not received antibiotic therapy within the last 3 months 4. Patients who have no known allergy to medications 5. Patients with at least 10 teeth in each jaw
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to TAP or specific antibiotic content such as patients with a history of seizures, myasthenia gravis, peripheral neuropathy, liver and kidney problems 2. Pregnant or lactating individuals 3. Patients on systemic antibiotics past 3 months 4. Smoking more than 10 cigarettes per day 5. Patients with a history of diabetes, cardiovascular disease and immune disorder 6. History of hypersensitivity to metronidazole, or minocycline, or ciprofloxacin 7. Patients on immunosuppressant in the last 6 months 8. Periodontal treatment done in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured at baseline, 8 weeks and 3 months postoperatively using UNC-15 periodontal probe: 1. Pocket depth 2. Plaque reduction 3. Bleeding on probing 4. Clinical attachment level | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured using relative quantification at baseline and 8 weeks postoperatively: 1. Levels of IL-1ß, IL-6, IL-10 and TNF-a measured using the Luminex fluorescent technique, utilizing Milliplex Magnetic Beads (Merck Millipore, BA, USA) 2. Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) count using relative qPCR | — |
Countries
Malaysia
Contacts
Public ContactNursafirah 'izzati Binti;Muhammad Hilmi Bin Idrus;Zainal Ariffin
;
Outcome results
None listed