Skin ageing Skin and Connective Tissue Diseases
Conditions
Interventions
"Out" strategy: Melatonin-based cream 0.1%
"In" strategy: Mel-based (0.5 mg) dietary supplementation also containing hyaluronic acid (150 mg
HA) and apigenin (0.9 mg)
Participants were randomized in a 1:1 allocation ratio. They were also instructed to apply the cream twice a day using 2 ftu (fingertips units) for group A and the cream twi
Sponsors
Difa Cooper (Italy)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women with moderate/severe skin ageing defined as a Glogau Score higher than II
Exclusion criteria
Exclusion criteria: Skin acute conditions like eczema or skin cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Elasticity, wrinkles, roughness, pigmentation, erythema, and skin pores assessed using the Skin Aging Global Score (SAGS) at baseline, week 6 and week 12 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical evaluation of Skin ageing using the Glogau score at baseline, week 6 and week 12 2. Single parameters of SAGS measured at baseline, week 6 and week 12 3. Instrumental skin ageing evaluation using VISIA objective face sculptor analysis performed on a subgroup of 20 participants at baseline, week 6 and week 12 | — |
Countries
Italy
Contacts
Public ContactMassimo Milani
Outcome results
None listed