The effect of a 10 week exercise intervention on cancer related fatigue in cancer survivor’s with documented fatigue compared to a 10 week health education programme

Evaluation of a Sustainable Intervention using Exercise - for Cancer Fatigue (ESIE-CF Trial)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN58635908

Enrollment

Registered

2017-06-08

Start date

2015-06-26

Completion date

Unknown

Last updated

2022-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer related fatigue in post treatment cancer survivors Cancer Cancer related fatigue in post treatment cancer survivors

Interventions

This study is a quasi-experimental multi centre trial. A repeated measures design is being used comparing a ten week semi-supervised progressive exercise intervention to a non-exercise health educatio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Women and men 2. Aged 18 or older 3. Breast, colorectal and prostate cancer survivors 4. At least 6 weeks but not more than 10 years following the completion of surgery, radiotherapy and chemotherapy (to allow for stabilisation of fatigue following treatment) but not excluding those on ongoing hormonal therapy 5. Ongoing fatigue (FACT-F score <45) (the lower the score the higher the fatigue) 6. Currently undertaking less than 90 min or more of moderate intensity exercise weekly

Exclusion criteria

Exclusion criteria: 1. Inability to travel for testing and to group exercise/health education sites 2. GP unwilling to provide medical clearance for moderate intensity exercise 3. Orthopaedic limitations that render participant unable to participate in a class-based moderate intensity exercise programme 4. Currently undertaking 90 min or more of moderate intensity exercise weekly

Design outcomes

Primary

Measure	Time frame
Fatigue is measured using the FACT-F measured at baseline, week four, week eight, post intervention and at six month follow up.	—

Secondary

Measure	Time frame
1. Quality of life is measured using Quality of life (EORTC) questionnaire at baseline, post intervention, and at six month follow up 2. Fear of Physical Activity among breast cancer survivors is measured using Fear of Physical Activity and Exercise in Survivors of Breast Cancer questionnaire at baseline, post intervention, and at six month follow up 3. Sleep difficulties are measured using Insomnia Severity Index at post intervention, and at six month follow up 4. Self-efficacy in general health management is measured using the Perceived Health Competency questionnaire at baseline, post intervention, and at six month follow up 5. Fitness is measured using the six minute walk/run test, handgrip dynamometer, sit to stand test, sit & reach test and the one legged balance test at baseline, post intervention, and at six month follow up 6. Vascular function is measured using the arterial stiffness via pulse wave velocity at baseline, post intervention, and at six month follow up 7. Body weight, height and blood pressure are measured at baseline, post intervention, and at six month follow up 8. Physical activity levels are measured using the International Physical Activity Questionnaire (IPAQ) at baseline, post intervention, and at six month follow up 9. Salivary cortisol are measured using saliva samples at baseline and post intervention 10. Cytokines are measured using blood samples at baseline, post intervention, and at six month follow up	—

Measure

Time frame

1. Quality of life is measured using Quality of life (EORTC) questionnaire at baseline, post intervention, and at six month follow up 2. Fear of Physical Activity among breast cancer survivors is measured using Fear of Physical Activity and Exercise in Survivors of Breast Cancer questionnaire at baseline, post intervention, and at six month follow up 3. Sleep difficulties are measured using Insomnia Severity Index at post intervention, and at six month follow up 4. Self-efficacy in general health management is measured using the Perceived Health Competency questionnaire at baseline, post intervention, and at six month follow up 5. Fitness is measured using the six minute walk/run test, handgrip dynamometer, sit to stand test, sit & reach test and the one legged balance test at baseline, post intervention, and at six month follow up 6. Vascular function is measured using the arterial stiffness via pulse wave velocity at baseline, post intervention, and at six month follow up 7. Body weight, height and blood pressure are measured at baseline, post intervention, and at six month follow up 8. Physical activity levels are measured using the International Physical Activity Questionnaire (IPAQ) at baseline, post intervention, and at six month follow up 9. Salivary cortisol are measured using saliva samples at baseline and post intervention 10. Cytokines are measured using blood samples at baseline, post intervention, and at six month follow up

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Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026