Finger capillary refilling time variations to evaluate effects of fluid administration in critically ill patients

Capillary refill time for the assessment fluid bolus tissue perfusion effects in critically ill patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN58464956

Enrollment

100

Registered

2021-03-04

Start date

2021-03-01

Completion date

Unknown

Last updated

2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypovolemia (loss of blood volume) in critically ill patients Nutritional, Metabolic, Endocrine Volume depletion

Interventions

1) Passive leg raising manoeuvre if it is possible according to the clinical situation 2) Patient’s finger will be firmly compressed for 10 sec. The whole procedure will be recorded with a smartphone

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Central venous line present in internal jugular vein and arterial line 2. PvaCO2 >6mmHg

Exclusion criteria

Exclusion criteria: 1. Age 75mmHg before or after FB 5. FB for acute bleeding 6. Admission to ICU or hemodynamic instability for less than 6 hours 7. Interventions (i.e. changes in ventilator parameters, change in the dose of inotropes) within 1h before FB 8. Severe peripheric vasoconstriction or hypothermia: not possible to evaluate peripheral saturation with pulse oximetry

Design outcomes

Primary

Measure	Time frame
Measured before, during, and after intake of the fluid bolus: 1. Capillary refilling time measured using a chronometer 2. PvaCO2 measured using blood gas analysis with using blood gas analysis devices (RAPID Point 500®; Siemens Health-care Limited, Germany)	—

Secondary

Measure	Time frame
Measured before, during, and after intake of the fluid bolus: 1. Cardiac index measured with transthoracic echocardiography 2. Mean arterial pressure measured using sphygmomanometer	—

Countries

Belgium, Greece

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 22, 2026