Recurrent implantation failure associated with poor embryo development that cannot be overcome by standard IVF Urological and Genital Diseases
Conditions
Interventions
Patient and donor are usually stimulated simultaneously via standard stimulation protocols in order to achieve simultaneous oocyte retrieval and fertilization. In some instances, follicular stimulatio
Sponsors
Nadiya Clinic
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. No less than two failed previous IVF attempts with preimplantation embryonic lethality (embryo arrest) 2. Low blastulation rates 3. Low number or absence of euploid embryos
Exclusion criteria
Exclusion criteria: 1. Fertile patients 2. Fertile homosexual female couples 3. Male factor infertility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Blastocyst rate measured using a non-invasive time-lapse imaging system on Day 5 – Day 7 post insemination 2. Euploidy rate measured via aCGH or NGS analysis of trophectoderm biopsy from embryos on Day 5 – Day 7 post insemination 3. Clinical pregnancy rate measured by rising beta hCG levels starting at 10 days post embryo transfer, presence of gestational sac at 6-7 weeks post embryo transfer, and presence of fetal heartbeat at 6-7 weeks post embryo transfer 4. Health of baby at birth and long-term follow-up, assessed by pediatrician examination on a yearly basis for the first 7 years, and then on a bi-yearly basis until age 18. This includes periodic completion of a quality of life questionnaire related to the offspring produced in the clinical trial | — |
Secondary
| Measure | Time frame |
|---|---|
| Miscarriage rates calculated from the patients who delivered babies to the total number of patients scored as clinically pregnant based on the primary outcome measure 3, calculated each month, quarter and annually | — |
Countries
Ukraine
Outcome results
None listed