Effectiveness of tailored and conventional therapy in H. pylori treatment of Vietnamese patients

Tailored versus conventional therapy in rescue treatment of Vietnamese patients with Helicobacter pylori: a randomized control trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN58374617

Enrollment

488

Registered

2022-03-02

Start date

2015-04-01

Completion date

Unknown

Last updated

2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection Infections and Infestations Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters

Interventions

Block randomization with a block size of 10 is used for randomly distributing participants into the two study groups. Patients are randomly assigned to the control group or the tailored group in a 1:1

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-95 years old 2. Had a confirmed H. pylori infection by urea breath test or PY test 3. Had a history of H. pylori treatment failure

Exclusion criteria

Exclusion criteria: 1. Younger than 18 years old 2. Received a treatment of antibiotics, antacids, or bismuth-containing drugs within 1 month before the study 3. Had gastric cancer or gastrointestinal bleeding

Design outcomes

Primary

Measure	Time frame
H. pylori eradication determined using a urea [14C] breath test (PY test) performed at week 6	—

Secondary

Measure	Time frame
1. Antibiotic resistance measured using minimum inhibitory concentration (MIC) test at the first hospital visit after patient enrolment 2. CYP2C19 polymorphism genotyping using real-time PCR and sequencing at the first hospital visit after patient enrolment	—

Countries

Viet Nam

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026