Can a new breathing device help people in hospital with severe flare ups of chronic lung disease clear mucus and breathe more easily?

Feasibility and benefits of an oscillatory negative-pressure device for secretion mobilization in patients hospitalized with acute COPD exacerbation - a randomized controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN58374348

Enrollment

Registered

2026-05-05

Start date

2024-11-01

Completion date

Unknown

Last updated

2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients hospitalized with acute exacerbation of COPD Respiratory

Interventions

Participants will be recruited by the attending physician in collaboration with a physiatrist, who confirmed the indication for respiratory rehabilitation. An initial interview will be conducted by on

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patient with confirmed diagnosis of COPD 2. Hospitalized with respiratory onset 3. With an increase of his usual secretion production

Exclusion criteria

Exclusion criteria: 1. Hemodynamic instability requiring vasopressor support 2. Severe respiratory failure defined as PaO2/FiO2 60% 4. Altered level of consciousness or inability to cooperate with the intervention 5. Untreated or undrained pneumothorax 6. Massive hemoptysis 7. Unstable cardiovascular disease (e.g., acute coronary syndrome, uncontrolled arrhythmias) 8. Any clinical condition requiring strict bed rest or contraindicating participation in respiratory physiotherapy

Countries

Portugal

Contacts

Public ContactManuel Fernandes

manuel.fernandes@ulsaave.min-saude.pt+351 916405680

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 22, 2026