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Effects of aloe vera hydrogel on healing of soft tissue of the mouth

Effect of aloe vera extracted Hydrogel on the healing of free gingival graft and palatal donor site

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN58370471
Enrollment
22
Registered
2021-02-16
Start date
2020-09-13
Completion date
Unknown
Last updated
2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival recession, free gingival graft healing Oral Health Gingival recession, free gingival graft healing

Interventions

Participants will be randomized to either the experimental group or the control group. Randomized using a method of pulling a sheet of 22 sheets, including 1 as a reference to the study sample on 11 s

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Width of attached gingiva 3 mm 3. Aged >18 years 4. Good oral health 5. Good systemic health

Exclusion criteria

Exclusion criteria: 1. Acute gingival inflammation or periodontitis 2. Uncontrolled plaque accumulation (hairy plaque >1) 3. Patients undergoing current orthodontic treatment 4. Patients with systemic conditions or taking medications that affect the healing of the periorbital tissue 5. Pregnancy and breast-feeding 6. Dental movement in the surgical area 7. Have received surgical dental treatment within the last six months

Design outcomes

Primary

MeasureTime frame
1. Graft shrinkage during follow-up periods measured using a computer program that measures graft dimensions through photographs taken at 7, 14, 21, 28, 60, and 90 days

Secondary

MeasureTime frame
1. Epithelization measured using examination of epithelial formation at the graft site and donor site with Toluidine blue in the donor and recipient regions at 7, 14, 21, 28, 60, and 90 days 2. Mucosal scar measured using Mucosal Scarring Index at 7, 14, 21, 28, 60, and 90 days 3. Pain in the donor and recipient regions is measured using a visual analog scale (VAS) at 2 h after surgery, and at 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 days 4. Healing in donor site measured using Wound Healing index (by Landry, Turnbull, and Howley) at 7, 15, 21, 28, 60, and 90 days

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026