Dementia Nervous System Diseases Dementia
Conditions
Interventions
Baseline versus rhythmic auditory cue versus rhythmic auditory cue at increased volume - a one-off assessment comparing patients baseline performance with performance under different experimental cond
Sponsors
King's College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Operationalised diagnosis of Dementia with Lewy Bodies (DLB), Parkinson?s Disease with Dementia (PDD), mild possible or probable Alzheimer?s Disease (AD), or Parkinson?s Disease (PD) 2. DLB and PDD patients must show clear signs of fluctuating cognition as indicated by a score eqaulling six on the One Day Fluctuation Assessment 3. Severity of dementia must be mild to moderate (Mini Mental State Examination [MMSE] greater than 14) 4. Capacity to give informed consent for participating in the study or Assent from Next of Kin (NOK) 5. Able to complete computerised test battery and understand instructions 6. Good hearing 7. Aged 63 - 89 years, either sex
Exclusion criteria
Exclusion criteria: 1. Symptoms or disabilities that would result in difficulties fulfilling the test requirements 2. Any diagnosis of another medical condition that in the eyes or the experimentor or investigator would prohibit partaking in the study 3. Ability to undergo 12 hour washout period from anti-parkinsonian medication before cognitive testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reaction time standard deviation, measured at intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at intervention: 1. Attentional performance 2. Reaction time 3. Tapping speed 4. Tracking precision 5. Electroencephalogram (EEG) mean frequency variability 6. Frequency of occurrence of stimulus independent thoughts | — |
Countries
United Kingdom
Outcome results
None listed