How effective is ionic silver and chlorhexidine (SiO2- Ag+ Chlorex) spray on pain and re-epithelialisation rate in donor site wounds for patients undergoing split skin grafting?

Effect of ionic silver and chlorhexidine (SiO2- Ag+ Chlorex) spray on pain and re-epithelialisation rate in donor site wounds for patients undergoing split skin grafting (SSG) - a study protocol

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN58295774

Enrollment

Registered

2021-02-08

Start date

2021-02-11

Completion date

Unknown

Last updated

2021-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Split skin grafting Surgery

Interventions

Current intervention as of 14/09/2021: After recruitment and baseline testing, patients will be randomly assigned to the KAdermin and Syncera Elect Hydro groups. A random allocation se

patients will be numbered and randomised into two groups. The allocation sequence will be sealed in identical opaque envelopes and given to the enrolling assessor upon receipt of patient consent. Asse

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. All patients undergoing split skin grafting using the thigh as a donor site 2. Consented patients

Exclusion criteria

Exclusion criteria: 1. Known allergy to any component of the dressings 2. Uncontrolled diabetes mellitus, as measured by HbA1c =10% 3. Presence of active autoimmune or immune diseases 4. Use of systemic steroid or immunosuppressants

Design outcomes

Primary

Measure	Time frame
Pain measured using Visual Analogue Scale (VAS) at rest and dressing removal at baseline, and postoperative days 1-7, 10, 15 and 20	—

Secondary

Measure	Time frame
Current secondary outcome measures as of 14/09/2021: 1. Re-epithelialisation rate of skin graft donor sites will be evaluated on postoperative days 5, 10, 15 and 20. During the wound assessment, standard photography with the same camera, settings and lighting condition will be carried out. The photographs will be assessed; epithelialisation percentage will be calculated by analysing the photographs of the donor sites using image software (Adobe Photoshop®). 2. Patient satisfaction will be measured with a questionnaire at Day 15 post SSG _____ Previous secondary outcome measures: 1. Re-epithelialisation rate of skin graft donor sites will be evaluated on postoperative days 5, 10, 15 and 20. During the wound assessment, standard photography with the same camera, settings and lighting condition will be carried out. The photographs will be assessed; epithelialisation percentage will be calculated by analysing the photographs of the donor sites using image software (Adobe Photoshop®). 2. Scarring will be assessed with the Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) at Day 15, 20 and 45 post SSG 3. Patient satisfaction will be measured with a questionnaire at Day 15 post SSG	—

Measure

Time frame

Current secondary outcome measures as of 14/09/2021: 1. Re-epithelialisation rate of skin graft donor sites will be evaluated on postoperative days 5, 10, 15 and 20. During the wound assessment, standard photography with the same camera, settings and lighting condition will be carried out. The photographs will be assessed; epithelialisation percentage will be calculated by analysing the photographs of the donor sites using image software (Adobe Photoshop®). 2. Patient satisfaction will be measured with a questionnaire at Day 15 post SSG _____ Previous secondary outcome measures: 1. Re-epithelialisation rate of skin graft donor sites will be evaluated on postoperative days 5, 10, 15 and 20. During the wound assessment, standard photography with the same camera, settings and lighting condition will be carried out. The photographs will be assessed; epithelialisation percentage will be calculated by analysing the photographs of the donor sites using image software (Adobe Photoshop®). 2. Scarring will be assessed with the Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) at Day 15, 20 and 45 post SSG 3. Patient satisfaction will be measured with a questionnaire at Day 15 post SSG

—

Countries

Malaysia

Contacts

Public ContactHani Atiqah Saim

dr.ishamuddin.hctm@ukm.edu.my+60 (0)173731025

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026