Malaria Infections and Infestations Malaria
Conditions
Interventions
Primary endpoint of coverage (% children requiring drug that got the drug) does not depend upon number of participants, therefore no exact number of participants. Community is the level of randomisati
Sponsors
UNICEF/UNDP/World Bank/WHO - Special Programme for Research and Training in Tropical Diseases (TDR)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children and adults of any age group 2. Clinical diagnosis of probable P. falciparum malaria 3. Consent by patient or parent guardian 4. Presence of one or more of the following conditions: 4.1. Repeated vomiting 4.2. Inability to eat, drink, or suck 4.3. Recurrent convulsions 4.4. Obtuned response to painful stimuli 4.5. Coma
Exclusion criteria
Exclusion criteria: 1. Children below three months age 2. Patients who are per os or can take drugs by mouth 3. Non-residents of the study area, unlikely to stay at least a week after treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The coverage of non per os patients achieved. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The time taken to deliver the drug to the patient 2. The proportion of non per os patients who followed referral advice 3. The proportion of non per os patients who took consolidation treatment 4. The proportion of non per os patients who needed the drug but were excluded from treatment, and the proportion of per os patients who were given treatment and should have been excluded from treatment 5. The convenience and acceptability of treatment via the provider 6. The training requirements for the drug dispensers 7. The handling and utilisation of rectal artesunate suppositories, adherence to correct treatment procedures, adherence to training in recognition, referral to hospital/provision of consolidation treatment 8. Recording of treatment outcome 9. Recording severe adverse reactions 10. Documentation: number of suppositories used, number of suppositories in the village stock | — |
Countries
Ghana, Guinea-Bissau, Tanzania, Uganda, Zambia
Outcome results
None listed