Treatment of inflamed dental implants

Therapy of peri-implantitis by electrolytical decontamination

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN57998865

Enrollment

Registered

2023-06-19

Start date

2020-11-01

Completion date

Unknown

Last updated

2023-07-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with osseointegrated oral implants with peri-implantitis lesions Oral Health

Interventions

Methodology: After conservative professional cleaning and biofilm removal, a local surgical intervention with flap elevation, removal of granulation tissue and surface decontamination by electrolytica

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with at least one osseointegrated and functionally loaded oral implant 2. Patients with at least one implant with peri-implantitis with local signs of inflammation, i.e. bleeding upon probing w/o suppuration 2.1. Increased probing depths 2.2. Radiographically visible loss of peri-implant bone 3. Removability of the supraconstruction of the implant

Exclusion criteria

Exclusion criteria: 1. Fracture of the implant 2. Malignancies 3. Mobility of the implant 4. Intake of immuno-suppressive drugs 5. Pregnancy 6. Systemic diseases with impact on treatability by local surgical interventions 7. Systemic therapy with bisphosphonates or monoclonal antibodies with impact on bone metabolism 8. Therapy with systemic antibiotics within 3 months before the study

Design outcomes

Primary

Measure	Time frame
Peri-implant bleeding measured using a periodontal probe (PCPUNC 15) at baseline and at 4 weeks, and 3, 6 and 12 months after treatment	—

Secondary

Measure	Time frame
1. Peri-implant probing pocket depth measured using a periodontal probe (PCPUNC 15) at baseline and at 4 weeks, and 3, 6 and 12 months after treatment 2. Lack of peri-implant suppuration measured using visual inspection and probing the peri-implant sites at 4 weeks, and 3, 6 and 12 months after treatment 3. Reduction of the peri-implant bony defect measured using a periodontal probe by bone sounding at 6 and 12 months after treatment 4. Reduction of the red-complex bacteria in microbiological samples from the treated implants measured using 4 sterile paper points after the removal of all supra-mucosal deposits with a cotton pellet at 3, 6 and 12 months after treatment. Paper points are introduced into the peri-implant pocket until slight resistance and remain in situ for 30 secs. They are then put in sterile tubes and sent to a commercial microbiological laboratory for analysis.	—

Measure

Time frame

1. Peri-implant probing pocket depth measured using a periodontal probe (PCPUNC 15) at baseline and at 4 weeks, and 3, 6 and 12 months after treatment 2. Lack of peri-implant suppuration measured using visual inspection and probing the peri-implant sites at 4 weeks, and 3, 6 and 12 months after treatment 3. Reduction of the peri-implant bony defect measured using a periodontal probe by bone sounding at 6 and 12 months after treatment 4. Reduction of the red-complex bacteria in microbiological samples from the treated implants measured using 4 sterile paper points after the removal of all supra-mucosal deposits with a cotton pellet at 3, 6 and 12 months after treatment. Paper points are introduced into the peri-implant pocket until slight resistance and remain in situ for 30 secs. They are then put in sterile tubes and sent to a commercial microbiological laboratory for analysis.

—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026