The effects of dexmedetomidine on cerebral blood flow and cerebral metabolic rate

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN57998533

Enrollment

Registered

2011-10-10

Start date

2011-09-20

Completion date

Unknown

Last updated

2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury (TBI), cerebral blood flow (CBF) and cerebral metabolic rate (CMR) Injury, Occupational Diseases, Poisoning Intracranial injury, unspecified

Interventions

The German Philips Intellivue MP20 multi-function monitor is used for continuous monitoring of SBP, DBP, MAP, HR, RR and SpO2, and color Doppler ultrasound (esaote MyLab40, Italy, frequency 7.5 ~ 10MH

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Electrocardiogram (ECG) examination was normal, no hypotension, no bradycardia, etc 2. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Brain tumor, hypertensive cerebral hemorrhage and non-traumatic brain injury patients 2. Patients combined heart failure, liver dysfunction, renal insufficiency, cardiac arrhythmias 3. Patients combined severe primary liver disease, severe primary renal disease, severe primary hematopoietic system diseases or mental illness 4. Pregnancy or breastfeeding women 5. Patients with allergies 6. Patients participating in other clinical trials

Design outcomes

Primary

Measure	Time frame
Cerebral blood flow	—

Secondary

Measure	Time frame
1. Cerebral metabolic rate of oxygen 2. The dosage of dopamine 3. Diastolic blood pressure 4. Systolic blood pressure 5. Mean arterial pressure 6. Heart rate 7. Respiratory rate 8. Oxygen saturation 9. PaCO2	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 22, 2026