Myocardial infarction and depression Circulatory System Acute myocardial infarction
Conditions
Interventions
Patients in the intervention arm were offered several treatment options according to a strictly defined protocol:
First-choice treatment was double-blind placebo-controlled treatment with the selecti
Sponsors
The Netherlands Heart Foundation (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hospital admission for myocardial infarction, defined as: Documentation of an increase in cardiac enzymes and either electrocardiographic changes and/or chest pain (Enzyme changes: elevation of creatine kinase isoenzyme (CK-MB) (CK-MB _1_ ULN and CK-MB/CK ratio above the local normal limit) or in case CKMB is not available, elevation of total CK (total CK _2 _ ULN); electrocardiographic changes: new significant Q waves in at least 2 out of 12 leads or new R in V1 with R/S ratio _1; Chest pain: _20 minutes of new or markedly increased chest pain) 2. Age more than or equal to18 years 3. Signed informed consent for study
Exclusion criteria
Exclusion criteria: 1. Occurrence of MI while the patient was hospitalized for another reason, except for unstable angina pectoris 2. Lacking capability to participate in study procedures (ie, patients notable to communicate and patients not available for follow-up) 3. Any disease likely to influence short-term survival 4. Already receiving psychiatric treatment for depression 5. Participation in any clinical trial that might intervene with the study objectives and/or safety of the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence of any significant cardiac event. Cardiac events included: 1. Cardiac death or hospital admission for documented non-fatal myocardial infarction 2. Myocardial ischaemia 3. Coronary revascularisation (coronary angioplasty or bypass surgery) 4. Heart failure or ventricular tachycardia occurring in the time between randomisation and 18 months postmyocardial infarction | — |
Secondary
| Measure | Time frame |
|---|---|
| Other cardiac-related hospital admissions (defined as admissions with an initial evaluation by a cardiologist or hospitalisations at the cardiology ward) | — |
Countries
Netherlands
Outcome results
None listed