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Manchester Adolescent Varicocele Study

Open randomised control study to assess the impact on fertility of early surgery in adolescents with varicocele

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN57825419
Enrollment
126
Registered
2011-11-24
Start date
2011-04-01
Completion date
Unknown
Last updated
2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicocele Urological and Genital Diseases Scrotal varices

Interventions

All patients referred with a varicocele, will be examined by a consultant paediatric urologist to assess the pubertal stage and the severity of the varicocele. A doppler ultrasound will be performed

Sponsors

Central Manchester Foundation NHS Trust (UK)
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
14 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. Between ages of 14-17 years at recruitment to study 2. Have a clinically detectable varicocele 3. High grade reflux on Doppler ultrasound (grade 2 or 3)

Exclusion criteria

Exclusion criteria: 1. Children younger than 14 years of age or older than 17 years at time of recruitment to study 2. Testicular growth arrest 3. Previous inguinal surgery 4. Orchitis 5. Epididymo-orchitis 6. Testicular torsion 7. Endocrinological disorders

Design outcomes

Primary

MeasureTime frame
To compare the trend in semen analysis between the two groups: 1. Percentage normal semen quality (according to the WHO criteria) 2. Percentage of motile sperm 3. Mean concentration of sperm (million per millilitre)

Secondary

MeasureTime frame
Difference in testicular volume (ml) between the affected side (with the varicocele) and the contralateral testis. The testicular sizes will be measured every 6 months.

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 13, 2026