Cardiovascular Circulatory System
Conditions
Interventions
Additional inorganic nitrite vs no additional inorganic nitrite
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Added 27/02/2008: 1. Healthy subjects 2. Aged 18-45 3. Have volunteered themselves and are willing to sign the consent form
Exclusion criteria
Exclusion criteria: Added 27/02/2008: 1. Healthy subjects unwilling to consent 2. History of hypertension, diabetes or hypertensive on BP measurement 3. Pregnant or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result 4. History of any serious illnesses, including infectious diseases as above 5. Subjects taking systemic medication (other than the oral contraceptive pill)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Added 27/02/2008: Reduction in forearm endothelial dysfunction (responses to acetylcholine) due to ischaemia-reperfusion with pre-ischaemic infusion of sodium nitrite | — |
Secondary
| Measure | Time frame |
|---|---|
| Added 27/02/2008: Effect of nitrite on reperfusion | — |
Countries
United Kingdom
Outcome results
None listed