Comparing two different doses of praziquantel in Lao school children to treat infections of Schistosoma mekongi and Opisthorchis viverrini

Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose comparison

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN57714676

Enrollment

308

Registered

2011-05-05

Start date

2007-02-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schistosoma mekongi and Opisthorchis viverrini infections Infections and Infestations Schistosoma mekongi infection

Interventions

1. Praziquantel 40 mg / kg body weight (1 dose) versus 2. Praziquantel 75 mg / kg body weight (divided into 2 doses of 50 mg/kg + 25 mg/kg, 4 hours apart)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. School children (males and females) between 6-16 years

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Severe illness 3. Non-consent

Design outcomes

Primary

Measure	Time frame
Schistosoma mekongi and Opisthorchis viverrini infection clearance (no eggs in 3 stool samples examined with Kato-Katz technique) at 28 and 90 days after treatment.	—

Secondary

Measure	Time frame
1. Reduction of intensity of infection (reduction of mean number of S. mekongi and O.viverrini eggs per gram of stool sample assessed by Kato-Katz technique) at 28 and 90 days after treatment 2. Diagnostic sensitivity of increasing number of Kato-Katz thick smears before and 28 days after treatment. 'Gold' standard: 9 Kato-Katz thick smears (applied on a sub-sample of the population)	—

Countries

Laos

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 25, 2026