Digestive system diseases: Peptic ulcer disease Digestive System Peptic ulcer disease
Conditions
Interventions
Treatment for H. pylori versus placebo
Sponsors
NHS R&D Regional Programme Register - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 50-59 years from selected General Practice (GP) surgeries (including asymptomatic volunteers as well as patients with dyspepsia)
Exclusion criteria
Exclusion criteria: 1. Severe mental illness 2. Severe medical illness that would make the subject unable to survive for two years 3. Allergy to proton inhibitors, clarythromycin or metronizadole 4. Unwillingness to abstain from alcohol whilst taking antibiotics 5. Pregnancy 6. Concomitant prescription of cisapride, warfarin, antihistamines or theophyllines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Absence of dyspepsia at two years 2. NHS dyspepsia costs for two years after the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Dyspepsia subgroups 2. Quality of life 3. H. pylori eradication rates 4. Adverse events | — |
Countries
United Kingdom
Outcome results
None listed