Overweight/obese inactive and sedentary adults with type 2 diabetes not using insulin medication Nutritional, Metabolic, Endocrine
Conditions
Interventions
Following baseline assessment and familiarisation participants will be scheduled to visit the laboratory for four acute experimental conditions each 7 hours in duration. These conditions are: prolonge
new participants will be randomly assigned a permutation from a new batch of 26 permutations sampled without replacement.
The four conditions are as follows:
1. SIT: after a 30 min seated steady-s
Sponsors
South Eastern Finland University of Applied Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 35 or more years; 2. Have a body mass index (BMI) between 25-50 kg/m²; 3. Be medically diagnosed with T2D for at least three months 4. T2D to be treated by diet alone or with oral hypoglycaemic agents or GLP1 agonists and be on stable treatment regimen for > 3 months 5. Inactive (less than 150 minutes per week of self-reported moderate-to-vigorous physical activity and regularly sits for > 7 hours per day for > 3 months)
Exclusion criteria
Exclusion criteria: 1. Using insulin to treat T2D 2. HbA1c >10% (reflects uncontrolled glycemic levels); 3. Current smoker 4. Pregnant 5. Women of childbearing potential not currently using adequate contraception 6. Major illness/physical problems (acute or chronic) that may limit participation in the intervention. 7. Unable to communicate in Finnish 8. Unable to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose and insulin 6,5h iAUC collected every 30 minutes using an indwelling catheter inserted into an antecubital vein | — |
Secondary
| Measure | Time frame |
|---|---|
| During experimental conditions: 1. Triglycerides 6,5h iAUC 2. Quadriceps, hamstring and gluteal usual EMG bout amplitude, usual EMG bout duration; EMG duration 3. Systolic and diastolic blood pressure 4. Central (aortic) systolic blood pressure (aoSBP), central (aortic) pulse pressure (aoPP), aortic augmentation index (aoAix), and aortic pulse wave velocity (aoPWV) 6,5h iAUC 5. Self-perceived energy, mood, alertness, productivity, focus, fatigue Sustained effects post experimental conditions: 6. CGM (during 24h post-condition): Average 24 hour glucose, 24-hour net iAUC, Time in range TIR & time above range >=10 mmol/l TAR, Glucose variation (CV; SD; CONGA), average at different times: pre-breakfast post-breakfast, iAUC and peak at different times: pre-breakfast / post-breakfast Exploratory outcomes during habitual living: 7. EMG: Quadriceps, hamstring and gluteal average EMG amplitude (aEMG), usual EMG bout amplitude, usual EMG bout duration; EMG duration 8. Sitting, standing, and physical activity metrics (Fibion, Fitbit) 9. CGM (after 24h post-condition): Average glucose, net iAUC, time in range (TIR) & time above range =10 mmol/l (TAR), Glucose variation (CV; SD; CONGA) | — |
Countries
Finland
Contacts
Public ContactArto J Pesola
Outcome results
None listed