Does CT-derived fractional flow reserve help reduce healthcare costs and improve patient care in a real-world setting?

CT-derived fractional flow reserve in stable heart disease and coronary computed tomography angiography helps improve patient care and societal costs

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN57392292

Enrollment

100000

Registered

2022-07-29

Start date

2022-03-01

Completion date

Unknown

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease Circulatory System

Interventions

Participants will include all individuals who had a CCTA performed at an institute participating in NHS England’s Innovation and Technology Payment (ITP) programme during 2018-2020. All CCTA 12 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =18 years 2. CCTA for the assessment of coronary artery disease (CAD)

Exclusion criteria

Exclusion criteria: 1. Age <18 years 2. Coronary artery calcium scoring alone 3. CCTA in addition to a second CT investigation for a non-coronary indication (CT transcatheter aortic valve implantation [TAVI], CT aorta) 4. Previous CCTA within 6 months 5. Prior coronary artery bypass graft (CABG)/myocardial infarction (MI) 6. Entry into a separate FFRCT research study during the study timeframe

Design outcomes

Primary

Measure	Time frame
Collected from NHS digital’s datasets for 90 days, 12 months and a minimum of 24 months follow-up post CCTA: 1. MI event rate, hospitalization for acute coronary syndrome, MI deaths and all-cause death 2. Downstream testing: numbers of non-invasive functional tests, and invasive coronary angiograms without revascularisation performed following the index FFRCT 3. Cost analysis: total cost to the NHS of the index test and all downstream investigations and hospital admissions	—

Measure

Time frame

Collected from NHS digital’s datasets for 90 days, 12 months and a minimum of 24 months follow-up post CCTA: 1. MI event rate, hospitalization for acute coronary syndrome, MI deaths and all-cause death 2. Downstream testing: numbers of non-invasive functional tests, and invasive coronary angiograms without revascularisation performed following the index FFRCT 3. Cost analysis: total cost to the NHS of the index test and all downstream investigations and hospital admissions

—

Secondary

Measure	Time frame
Collected from NHS digital’s datasets for 90 days, 12 months and a minimum of 24 months follow-up post CCTA: 1. Time to diagnosis - trust referral to treatment (RTT) time 2. Qualitative assessment of the impact of the FFRCT health technology	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026