Mild-Moderate hypertension particularly of the short-term period of pregnancy. Pregnancy and Childbirth Hypertension
Conditions
Interventions
Women will be randomised to either a 'less tight' group aiming for a dialstolic Blood Pressure (dBP) of 100 mmHg of maternal hypertension or a 'tight' group aiming for a diastolic BP of 85 mmHg of mat
Sponsors
University of Toronto Maternal, Infant and Reproductive Health Research Unit (Canada)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women 18 - 50 years old with mild to moderate non-proteinuric pre-existing or gestational hypertension that presents at 20-33+6 weeks gestation.
Exclusion criteria
Exclusion criteria: 1. dBP consistently less than 85 mmHg by home BP monitoring 2. Severe systolic hypertension 3. Proteinuria 4. Contraindication to either arm of the trial or to prolongation of pregnancy 5. Known lethal/major fetal anomaly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Mean dBP at 28, 32 and 36 weeks gestation 2. One/more serious perinatal complications or birth weight less than third centile | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinician compliance with treatment protocols 2. Women?s satisfaction with care 3. One/more serious maternal complications Other outcomes: 1. Very severe hypertension 2. Pre-eclampsia | — |
Countries
Canada
Outcome results
None listed