Customised topographic photorefractive keratectomy (PRK) followed by corneal cross-linking in a single procedure for progressive keratoconus

Comparison of cross linking alone and customised photorefractive keratectomy (PRK) followed by cross linking in the treatment of progressive keratoconus: a prospective non-randomised single centre trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN57262986

Enrollment

Registered

2010-02-18

Start date

2008-06-26

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus Eye Diseases Other disorders of cornea

Interventions

Customised topographic PRK and corneal cross-linking in a single procedure are performed in the worse keratoconic eye, while routine cross linking is performed on the fellow eye. The treatment lasts

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Documented progressive keratoconus 2. Corneal thinnest point: 450 micra 3. Hard contact lens and full spectacle correction intolerance 4. Aged over 18 years, either sex

Exclusion criteria

Exclusion criteria: 1. Corneal thinnest point less than 450 micra 2. History of ocular morbidity 3. Previous ocular surgery

Design outcomes

Primary

Measure	Time frame
Measured at 1, 3, 6, 12, and 18 months: 1. Visual acuity 2. Refraction 3. Corneal aberrations 4. Corneal topography	—

Secondary

Measure	Time frame
Measured at 1, 3, 6, 12, and 18 months: 1. Confocal microscopy 2. Anterior segment optical coherence tomography	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026