Fungal corneal ulcer, fungal keratitis Ear, Nose and Throat Keratitis
Conditions
Interventions
Forty eyes of forty patients randomized into two groups of 20 patients each.
Group 1:
Topical 5% natamycin eye drops 4 hourly, 0.3% ciprofloxacin hydrochloride eye drops four times a day, 2% homatrop
Sponsors
Dr Rajendra Prasad Centre for Ophthalmic Sciences (India)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with a smear or culture proven fungal ulcers 2. Ulcers greater than 2mm in size, involving more than one-third of the stromal thickness and not showing any signs of clinical improvement after two weeks of natamycin 3. Patients who were willing to be treated as an inpatient, willing to follow up regularly, and return for medications regularly every 48-72 hours
Exclusion criteria
Exclusion criteria: 1. Patients with mixed infection on smear or culture, evidence of herpetic keratitis on history or examination, impending perforation, bilateral ulcers, those with vision less than 6/60 in the other eye, pre-existing scar not distinguishable from the new ulcer 2. Those less than 18 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best Spectacle Corrected Visual Acuity (BSCVA) 3 months after intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to healing | — |
Countries
India
Outcome results
None listed