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A randomised, open, comparison of penicillin and metronidazole for the treatment of tetanus

A randomised, open, comparison of penicillin and metronidazole for the treatment of tetanus

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN57194591
Enrollment
Unknown
Registered
2005-10-14
Start date
1993-04-01
Completion date
Unknown
Last updated
2022-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tetanus Infections and Infestations Tetanus

Interventions

Patients entered into the study were randomised to receive: 1. Benzylpenicillin 2 million units (child 25,000 units/kg) IV six-hourly for seven days 2. Metronidazole 1

Sponsors

University of Oxford (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Clinical diagnosis of tetanus 2. Aged more than one month 3. Informed consent from patient or attendant relative (if comatose or aged less than 16 years)

Exclusion criteria

Exclusion criteria: Lack of informed consent or age less than one month

Design outcomes

Primary

MeasureTime frame
The primary endpoint was mortality.

Secondary

MeasureTime frame
The secondary endpoints were recovery times and complication rates.

Countries

Bangladesh, Thailand

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026