A study to investigate the effects of voluntary coughing on the airways of asthmatic and COPD subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN57141601

Enrollment

Registered

2007-09-28

Start date

2006-10-30

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory: Chronic obstructive pulmonary disease (COPD) Respiratory Chronic obstructive pulmonary disease (COPD)

Interventions

Subjects will be randomised to either progressively increasing periods of voluntary coughing or no intervention, both interspersed with measurements of lung function.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged over 18 2. Physician diagnosed asthma or COPD

Exclusion criteria

Exclusion criteria: 1. Symptoms of upper respiratory tract infection or asthmatic/COPD exacerbation in the preceding 4 weeks 2. Involved in studies with licensed drugs or methodological studies within the preceding 4 weeks 3. Subjects taking ACE inhibitors, leukotrine receptor antagonists or cough suppressants 4. Change in asthma/COPD medication in last 4 weeks 5. Pregnancy 6. Current smokers

Design outcomes

Primary

Measure	Time frame
The fall in exhaled nitric oxide (eNO) following voluntary coughing.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026