Menstrually related migraine (MRM)
Conditions
Interventions
A total of 184 patients are randomly divided into two different groups:
1. Treatment group: Acupuncture (preventive treatment on migraine and premenstrual conditioning) and placebo me
Sponsors
Beijing Municipal Science and Technology Commission (China)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients who met diagnostic criteria for menstrually related migraine (International Headache Society Classification of Menstrually Related Migraine, 2nd edn, 2004) 2. Regular menstrual cycle lasting 30±10 days 3. Be able to predict the cycle and the onset period of menstrual related migraine 4. Patients suffered a repeated migraine attacks, frequency of non-menstrual migraine is more than once a month 5. Effective contraception and no plan to become pregnant during the study 6. Patients who took part in the trial voluntarily and signed the informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients who are diagnosed as chronic migraine(headache caused by drug abuse is included), tension-type headache, cluster headache, algopsychalia tension-type headache, cluster headache, other primary headache disorders 2. Patients suffered relatively severe systemic disease, such as cardiovascular diseases, acute infectious disease, hematopathy, endocrinopathy, allergy and methysis 3. Patients suffered otorhinolaryngology diseases which may cause headache, such as glaucoma, otitis, sinusitis, pericoronitis of wisdom tooth 4. Patients who suffered headache caused by intracranial pathological changes, such as intracranial infection, brain tumours, subarachnoid hemorrhage 5. The blood pressure is not controlled ideally 6. The menses cycle is erratical because of polycystic ovary and other gynecologic diseases, and the time of which is hard to predict 7. Patients who have been taking contraceptives or accepting other hormone therapy during the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The change of migraine days inside the menstrual cycle 2. The proportion of responders (defined as the proportion of patients with at least a 50% reduction in the number of menstrual migraine days) Recording headache diaries for four continuous menstrual cycles that included three months (consecutive menstrual cycles) during treatment and one month (menstrual cycle) after treatment. All assessments will be conducted at the baseline and at week 12 and 16 follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The change of migraine days outside the menstrual cycle 2. Duration of migraine attack 3. Visual analogue scale (VAS, 0 to 10 cm) for pain 4. Amount of migraine medication used Recording headache diaries for four continuous menstrual cycles that included three months (consecutive menstrual cycles) during treatment and one month (menstrual cycle) after treatment. All assessments will be conducted at the baseline and at week 12 and 16 follow-up. | — |
Countries
China
Outcome results
None listed