Spinal cord injury (SCI), moderate-intensity exercise, metabolic health, obesity, cardiovascular disease Injury, Occupational Diseases, Poisoning
Conditions
Interventions
Current interventions as of 01/02/2016:
Participants will be randomly assigned to either a 6-week home-based exercise intervention or a control group at a ratio of 2:1, using a minimisation approach a
Sponsors
University of Bath (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Individuals with a chronic SCI (> 12 months post-injury) below T2 or other disabling condition with a similar level of impairment 2. Motor-complete SCI (American Spinal Injury Association scale A or B) 3. Aged between 18 to 65 years 4. Objectively measured physical activity level = 1.6 5. Regular manual wheelchair user (> 70% of ambulation)
Exclusion criteria
Exclusion criteria: 1. Individuals with an acute SCI (< 12 months post-injury) 2. Pregnant women 3. Under 18 years old 4. Cardiovascular contra-indications for testing according to the American College of Sports Medicine (ACSM) 5. Severe musculoskeletal complaints of the upper extremities that contraindicate performance of wheelchair propulsion/arm crank ergometry 6. Individuals with active medical issues; pressure sores, urinary tract infections, or heart disorders 7. Plans to change lifestyle, e.g. diet or physical activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in insulin sensitivity and glycaemic control measured at baseline and at the end of the intervention/control (i.e. after 6 weeks). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Other blood measurements related to metabolic function and inflammation (e.g. cholesterol, non-esterified fatty acids (NEFA), triacylglycerol, interleukin-6 [IL-6], leptin and adiponectin) 2. Changes in maximal oxygen uptake, peak power and upper body strength 3. Changes in body composition 4. Changes in adipose tissue gene/protein expression related to metabolic function and inflammation 5. Changes in immune competency 6. Changes in quality of life and other psychological variables focussed around self-efficacy, independence and fatigue 7. Changes in physical activity and eating behaviours Measured at baseline and at the end of the intervention (i.e. after 6 weeks) | — |
Countries
United Kingdom
Outcome results
None listed