Topic: Metabolic and Endocrine
Conditions
Interventions
Participants are supplemented with either 40 g/day resistant starch (fibre) for 8 weeks compared to a placebo supplement which is energy matched.
Study entry: single randomisation only
Sponsors
University of Surrey (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Non-diabetic 2. No history of cardiovascular, endocrine or gastrointestinal disease 3. Male and female over the age of 18 years 4. Fasting plasma insulin greater than 60 pmol/l
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin sensitivity measured with hyperinsulinaemic euglycaemic clamp at end of each 8 week intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. mRNA expression in adipose tissue biopsies taken at end of each 8 week intervention 2. Postprandial meal handling and arteriovenous uptake of glucose measured at end of each 8 week intervention | — |
Countries
United Kingdom
Outcome results
None listed