Obstructive sleep apnea Respiratory Obstructive sleep apnea
Conditions
Interventions
Patients are randomised into one of two groups using sealed closed opaque envelopes.
Group 1: Patients receive a loading dose infusion of Dexmedetomine 1 ug/kg over 10 minutes followe
Sponsors
Beni Suef University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years 2. Obstructive sleep apnea 3. Require mechanical ventilation postoperatively
Exclusion criteria
Exclusion criteria: 1. Prolonged sedation and mechanical ventilation 2. Epileptic patient 3. Patients with known allergy to the studied drugs 4. Pregnancy 5. Severe hepatic, renal or cardiac diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Duration of mechanical ventilation and stay in the SICU is measured in hours 2. Mean time to extubation is measured in minutes 3. Sedation level is assessed using Ramsay sedation scores at baseline, 1 hour after start of the sedation and then every 3 hours until weaning from mechanical ventilation and extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Heart rate is measured by ECG at baseline, 1 hour after start of the sedation and then every 3 hours until weaning from mechanical ventilation and extubation 2. Invasive mean blood pressure is measured by arterial line at baseline, 1 hour after start of the sedation and then every 3 hours until weaning from mechanical ventilation and extubation 3. Oxygen saturation is measured by pulse oximetry at baseline, 1 hour after start of the sedation and then every 3 hours until weaning from mechanical ventilation and extubation | — |
Countries
Egypt
Outcome results
None listed