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Nurture-U Treating Anxiety and Depression: internet-based cognitive-behavioural therapy for anxiety and depression in UK university students

Developing and evaluating a stepped change whole-university approach for student wellbeing and mental health: Nurture-U trial of unguided versus guided internet cognitive-behavioural therapy for acute depression and anxiety in students

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN56784470
Enrollment
720
Registered
2022-10-27
Start date
2023-07-10
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression and anxiety Mental and Behavioural Disorders

Interventions

Two intervention groups: unguided transdiagnostic online CBT for anxiety and depression (i.e., without any therapist support)
guided transdiagnostic online CBT for anxiety and depression (i.e., with therapist support from psychological wellbeing practitioner – typically online, asymmetric support). Treatment duration is typi

Sponsors

University of Exeter
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 16 years plus based in the UK, attending university (predominantly one of the six partner universities: Exeter, Oxford, Southampton, Cardiff, Newcastle, King’s College London or other HE institution or associated HE institution, e.g., Falmouth University for University of Exeter) 2. Reporting PHQ-9>9 and/or GAD-7 >9 3. Basic literacy in English as indicated by ability to complete consent and online questionnaires (12-year-old reading age or better) 4. Ability to provide informed consent 5. Available for the full duration of the study (3 months) 6. Regular access to a relevant smartphone/tablet/laptop or PC able to run the intervention (using Android or IOS systems)

Exclusion criteria

Exclusion criteria: 1. Meeting criteria on self-report electronic screening questionnaires for any of the following: 1.1. Active suicidality 1.2 Any history of severe mental health problems (i.e., bipolar/psychosis/mania/drug/alcohol dependence) 2. Currently receiving psychological therapy or counselling 3. Currently receiving antidepressants or other psychiatric medication that has been changed within the last 4 weeks (in this instance the participant has the option to join the trial once stable for 4 weeks)

Design outcomes

Primary

MeasureTime frame
Current primary outcome measure as of 15/08/2023: Depression is measured using the PHQ-9 and anxiety is measured using the GAD-7 across the 3- month follow up Previous primary outcome measure: Depression is measured using the PHQ-9 across the 3-month follow up

Secondary

MeasureTime frame
1. Worry is measured by the short-form Penn State Worry Questionnaire at 3 months 2. Rumination is measured by the 5-item Brooding Scale at 3 months 3. Resilience is measured by the Brief Resilience Scale at 3 months 4. Stress is measured by the Perceived Stress Scale-7 and an abbreviated version of the post-secondary student stressors index at 3 months 5. Use of services/treatment received is self-reported at 3 months 6. Treatment satisfaction is measured with the Adapted Client Satisfaction Questionnaire – Internet-based interventions at 3 months 7. Self-report of use of intervention at 3 months

Countries

England, United Kingdom

Contacts

Public ContactEd Watkins
teamnurture-U@exeter.ac.uk+44 (0)1392 724692

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026