Hypertension Circulatory System Hypertension
Conditions
Interventions
Group one: patients receive antihypertensive treatment on the basis of self blood pressure measurement.
Group two: patients are treated based on conventional office blood pressure meas
Sponsors
The Netherlands Organisation for Health Research and Development (ZonMw) (The Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Males and females aged 18 years and above 2. Average blood pressure between 139 and 200 mmHg for systolic or between 90 and 120 mmHg for diastolic blood pressure 3. Participating subjects are physically and mentally able to measure their own blood pressure 4. Subjects are willing to remain in follow-up during a period of one year 5. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. The presence of clinically manifest cardiovascular events (angina pectoris, heart failure, hypertensive encephalopathy, or prior myocardial infarction or cerebrovascular accident) 2. Severe non-cardiovascular disease (e.g. malignancy), which will interfere with adequate follow up 3. Allergy or contra-indications for the antihypertensive drugs used in this study 4. Serum creatinine above 150 micromol/l 5. Clinically significant orthostatic hypotension (a drop in systolic blood pressure of more than 20 mmHg upon standing) 6. Blood pressure devices
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Blood pressure value (conventional office blood pressure and 24 hour ambulatory blood pressure) 2. Target organ damage (kidney, heart) 3. Cost and number of antihypertensive drugs | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Compliance with treatment 2. Quality of life | — |
Countries
Netherlands
Outcome results
None listed