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Exploring the natural history of myopic maculopathy and optic neuropathy in high myopia: Zhongshan High Myopia Cohort

Zhongshan High Myopia Cohort: the natural history of myopic maculopathy and optic neuropathy in individuals with high myopia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN56368396
Enrollment
600
Registered
2024-03-12
Start date
2023-03-13
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Individuals with high myopia Eye Diseases

Interventions

Current interventions as of 12/03/2024: The ZHMC study is a retrospective and prospective ambispective cohort study that includes individuals who completed the 8-year follow-up from Zhongshan Ophtha

Sponsors

National Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
7 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Sphere = -6.00 diopter (cylinder is not included) in both eyes 2. Aged between 7 and 70 years old

Exclusion criteria

Exclusion criteria: 1. Secondary myopia, such as a history of retinopathy of prematurity or neonatal problems, or syndromic myopia with a known genetic disease or connective tissue disorders, such as Stickler or Marfan syndrome 2. History of laser treatment for myopia correction or any intraocular surgery affecting refractive status 3. Have autoimmunity disease such as systemic lupus erythematosus, rheumatoid arthritis; 4. Have severe health problems precluding follow-up such as end-stage heart disease, kidney disease, lung disease, or terminal cancer 5. Have significant ocular media opacity preventing fundus examinations (e.g.dense corneal opacity) 6. Unable to give their own informed consent 7. Plan to move from the area within the next 8 years

Design outcomes

Primary

MeasureTime frame
The long-term development and progression of myopic maculopathy measured using fundus photography and optic neuropathy measured using optical coherence tomography and visual field in highly myopic populations and associated risk factors at baseline and each follow-up visit (2, 4, 6, and 8 years).

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

China

Contacts

Public ContactWei Wang
wangwei@gzzoc.com+86 (0)20 87334687

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026