Understanding the sources of tremor variability in patients with essential tremor, Parkinson’s, and dystonia – a non-invasive study of movement and brain signals

The use of portable magnetoencephalography (MEG) in movement disorders

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN56202806

Enrollment

Registered

2020-01-16

Start date

2020-03-01

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential tremor

Interventions

RECRUITMENT Patients suitable for this study will be identified by the clinical team who follow the clinical care of the patients. The invitation letter and PIS will be provided by the clinical team o

Eligibility

Sex/Gender

All

Age

25 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with Essential Tremor without DBS implants for standard clinical indications 2. Patients with Parkinson's disease and tremor dominant without DBS implants for standard clinical indications 3. Patients with Parkinson's disease and non-tremor dominant without DBS implants for standard clinical indications 4. Patients with Dystonic tremor without DBS implants for standard clinical indications 5. Patients between 25 - 80 years of age 6. Patients have the capacity to give informed consent 7. Patients are MRI safe - i.e. no metal implants, history of working in metal industry etc

Exclusion criteria

Exclusion criteria: 1. Cognitive impairment (judged by the clinician taking consent as not having sufficient mental capacity to understand the study and its requirements). This is including anyone who, in the opinion of the clinician taking consent is unlikely to retain sufficient mental capacity for the duration of their involvement in the study 2. Pregnancy 3. Severe claustrophobia 4. Head or neck muscle weakness/fatigue 5. Severe visual impairment

Design outcomes

Primary

Measure	Time frame
Regions involved in tremor-related networks imaged with great resolution using portable magnetoencephalography (MEG) during a set of motor tasks inducing tremor amplification and tremor suppression. Key data features include oscillatory power changes associated with different disease states. Measured at a single study visit.	—

Secondary

Measure	Time frame
Dynamic oscillatory profile of the non-tremor dominant PD network during movement, measured using using portable magnetoencephalography (MEG) at a single study visit	—

Countries

England, United Kingdom

Contacts

Public ContactHayriye Cagnan

h.cagnan@imperial.ac.uk+44 (0)1865 234829

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 23, 2026