Acute Myocardial Infarction Circulatory System Acute myocardial infarction, unspecified
Conditions
Interventions
Intervention:
Short term massive infusion of intravenous vitamin C (320 mmol/L)
Oral dose of vitamin E (400 IU/day) throughout the protocol
Oral dose of vitamin C (500 mg/12 hours) following angiop
Sponsors
Scientific and Technological Development Fund (FONDECYT Fondo de Desarrollo Científico y Tecnológico) (Chile)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects may be of either sex and must be at least 18 years old 2. Subjects must have indication of primary percutaneous coronary angioplasty (PCA) as follows: 2.1. Angina or equivalent at least 120 min duration 2.2. Electrocardiogram (ECG) with STEMI that concerns more than 2 contiguous leads (>2mm) 3. Presentation within 12 h of symptoms onset 4. First myocardial infarction 5. Subject must be able and willing to sign informed consent
Exclusion criteria
Exclusion criteria: 1. History of renal or hepatic insufficiency 2. History of renal lithiasis (oxalates) 3. History of heart failure (NYHA III, IV) 4. Cardiogenic shock 5. Any serious medical co-morbidity that determine life expectancy < 6 month 6. Current participation in any other clinical investigation 7. Pregnancy 8. Glucose 6-phosphate dehydrogenase deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infarct size, assessed by cardiac magnetic resonance (CMR) will be measured twice: 6 and 84 days following coronary angioplasty | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers for oxidative stress, antioxidant status, heart damage and inflammation will be measured at baseline, at the onset of reperfusion, 6-8 hours after revascularization and at hospital discharge. | — |
Countries
Chile
Outcome results
None listed