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Intensive versus conventional insulin therapy for inpatient medical patients [Insulinoterapia intensificada versus terapia habitual en pacientes hospitalizados por patología médica]

Intensive versus conventional insulin therapy for inpatient medical patients: a single centre randomised open trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN55845280
Enrollment
250
Registered
2009-09-23
Start date
2009-03-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperglycaemia Signs and Symptoms Elevated blood glucose level

Interventions

The project is based in the Universidad Católica de Chile Hospital, which is the main private facility of the Pontificia Universidad Católica de Chile, in Santiago, Chile. The clinical team in charge

Sponsors

National Fund of Investigation and Development in Health (Fondo nacional de investigación y desarrollo en salud [FONIS]) (Chile)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult inpatients (aged greater than 18 years, men and women) with an acute medical or surgical condition, and any of the following criteria: 1. In subjects known to have diabetes: Capillary blood glucose level over 180 mg/dl, in consecutive measurements separated by 2 hours, or just one measurement if insulin was administered after the first 2. In subjects without previous diagnosis of diabetes: Capillary blood glucose level over 200 mg/dl in consecutive measurements separated by 2 hours, or just one measurement if insulin was administered after the first

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Acute complications of diabetes 3. Terminal illness (expected survival of less than a month) 4. Elective hospitalisation 5. Hospitalisation stay predicted to last less than 72 hours 6. Haemodyalisis initiated during hospitalisation 7. Peritoneal dialysis 8. Corticosteroids (prednisone) dose over 30 mg/day 9. Parenteral nutrition 10. Inability to receive carbohydrates by mouth for more than 8 hours 11. Patients with an unresolved surgical condition

Design outcomes

Primary

MeasureTime frame
Number of measurements of blood glucose levels between 70 and 130 mg/dl. All measurements will be recorded at day 7 and at the moment of discharge.

Secondary

MeasureTime frame
1. Mean blood glucose level 2. Length of hospitalisation 3. Healthcare-associated infections 4. Number of measurements of blood glucose levels below 70 mg/dl 5. Time to achieve good glycaemic control (two or more measurements between 70 and 130 mg%) All measurements will be recorded at day 7 and at the moment of discharge.

Countries

Chile

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026