A double-blind, placebo-controlled, crossover trial of soy phytoestrogens in patients with compensated hypothyroidism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN55827330

Enrollment

134

Registered

2006-05-09

Start date

2006-04-10

Completion date

Unknown

Last updated

2019-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Compensated hypothyroidism Nutritional, Metabolic, Endocrine Hypothyroidism

Interventions

Soy protein alone versus soy protein with isoflavone in patients with compensated hyperthyroidism

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with newly diagnosed compensated hypothyroidism (thyroid stimulating hormone [TSH] >4.7 and normal T4)

Exclusion criteria

Exclusion criteria: 1. Patients on thyroxine or drugs that interfere with thyroid function 2. Patients who have had antibiotics within 3 months of starting the trial 3. Patients not wishing to allow disclosure to their general practitioners (GPs)

Design outcomes

Primary

Measure	Time frame
Change in thyroid stimulating hormone (TSH) and thyroxine levels as in hypothesis	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 21, 2026