Prevention of cardiovascular disease in periodontitis patients Circulatory System Cardiovascular disease in periodontitis patients
Conditions
Interventions
This is an observational trial. All participants will be asked to fill in questionnaires to gather data on their age, gender, ethnicity, medical history, perceived health, parental history, lifestyle
Sponsors
Amsterdam University Medical Centers
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 45 and 70 years 2. =10 teeth
Exclusion criteria
Exclusion criteria: 1. Known cardiovascular diseases 2. Known Diabetes Mellitus 3. Known autoimmune disorders 4. Known immunosuppressive disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Inflammatory and infectious burden of periodontitis measured using Periodontal Inflamed Surface Area (PISA) score calculated after extensive periodontal examination by trained and calibrated examiners from the following measured on all teeth, on six sites per tooth using a manual periodontal standard probe at baseline and 1 year 1.1 Periodontal probing pocket depth (PD) (in mm) 1.2. Gingival recession (in mm) 1.3. Clinical attachment loss (CAL), defined as the distance from the cementoenamel junction to the bottom of the pocket/sulcus and calculated as the mathematical sum of the PD and gingival recession measurements (in mm) 1.4. Plaque score defined as being present or absent at six points on each tooth 1.5. Bleeding on probing (BOP) recorded as either present or absent within 30 s of probing at six sites per tooth 1.6. Number of missing teeth 2. Predicted risk of future cardiovascular events measured using Coronary Artery Calcium Score (CAC) from cardiac computerized tomography scan at baseline 3. Endothelial dysfunction (EndoScore) measured using the EndoPAT at baseline and 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Risk of a future heart attack, stroke, or other major cardiovascular events in the next 10 years, measured using the Reynolds Risk Score calculated from the following: 1.1. A demographic information questionnaire (<age 60 years, current smoking, and parental history of a cardiovascular event) at baseline and 1 year 1.2. Blood pressure at baseline and 1 year 1.3. Blood samples (hs-CRP, and total and HDL cholesterol) at baseline and 1 year 2. 10-year risk of coronary artery disease events, measured using Framingham risk score calculated from the following: 2.1. A demographic information questionnaire (age, gender, and smoking status) at baseline and 1 year 2.2. Blood pressure at baseline and 1 year 2.3. Blood samples (total and HDL cholesterol) at baseline and 1 year 3. 10-year risk of cardiovascular disease mortality measured using the SCORE system, which for the Dutch population is calculated according to the algorithm for a low-risk country, calculated from: 3.1. A demographic information questionnaire (gender, and smoking status) at baseline 3.2. Blood pressure at baseline and 1 year 3.3. Blood samples (total and HDL cholesterol) at baseline and 1 year 4. Risk genes for both periodontitis and coronary heart disease measured using DNA analysis of a blood sample collected at baseline 5. Microbiological analysis of the oral microbiome measured using pyrosequencing of 16S microbial DNA from oral rinse sample and subgingival plaque collected at baseline | — |
Countries
Netherlands
Outcome results
None listed