Post-operative inflammatory and angiogenic response in patients with resectable colon cancer: a randomised clinical trial comparing open versus laparoscopic surgery

Randomised clinical trial of the inflammatory and angiogenic responses of open and laparoscopic surgery for colon cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN55624793

Enrollment

120

Registered

2009-08-19

Start date

2004-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon cancer Cancer Malignant neoplasm of colon

Interventions

Patients are randomised to either laparoscopic or open colectomy. Serum and peritoneal fluid samples are obtained at baseline, 12, 24 and 48 hours and post-operative day 4. Peritoneal fluid samples ar

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with resectable colon cancer, either sex 2. Written informed consent 3. Aged older than 18 years

Exclusion criteria

Exclusion criteria: 1. Patients with metastasic disease 2. Patients with locally advanced colon cancer 3. Patients undergoing emergency surgery 4. Transverse colon and splenic flexure cancer 5. Patients with a second neoplasm

Design outcomes

Primary

Measure	Time frame
1. Post-operative vascular endothelial growth factor (VEGF) serum and peritoneal fluid levels 2. Post-operative platelet derived growth factor (PDGF) serum and peritoneal fluid levels 3. Microvascular density determined in serum and peritoneal fluid on in vitro angiogenesis assay 4. Capillary length determined in serum and peritoneal fluid on in vitro angiogenesis assay Samples obtained at baseline, 12, 24 and 48 hours and post-operative day 4.	—

Measure

Time frame

1. Post-operative vascular endothelial growth factor (VEGF) serum and peritoneal fluid levels 2. Post-operative platelet derived growth factor (PDGF) serum and peritoneal fluid levels 3. Microvascular density determined in serum and peritoneal fluid on in vitro angiogenesis assay 4. Capillary length determined in serum and peritoneal fluid on in vitro angiogenesis assay Samples obtained at baseline, 12, 24 and 48 hours and post-operative day 4.

—

Secondary

Measure	Time frame
1. Levels of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) determined in serum and peritoneal fluid 2. Correlation between pro-inflammatory and angiogenic cytokines Samples obtained at baseline, 12, 24 and 48 hours and post-operative day 4.	—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 31, 2026