Postherpetic neuralgia Nervous System Diseases Postzoster neuralgia
Conditions
Interventions
PHN patients were randomized to receive pregabalin 150mg twice a day (Bid) or placebo for 2 weeks.
Rescue medication: Oxycodone 5-30mg/day or more orally was used as rescue medication for pain contro
Sponsors
Xinhua Hospital (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age greater than 60 years and over 40kg of body weight 2. Pain history is longer than 3 months 3. Pain on Visual Analogue Scale (VAS) >3 (0-10 VAS scale), the frequency of acute pain flares occurred more than 3 times per day 4. Refractory to formal treatment such as antiepileptic medicine, antidepressants, opioids and physical treatments and epidural block 5. No history of severe liver and renal diseases
Exclusion criteria
Exclusion criteria: 1. Withdraws from the study 2. Poor effect, intolerant to the study 3. Uncooperative and unable to finish the self evaluation (VAS, qulaity of life [QOL] and SF-36) 4. Coagulation disturbances 5. Allergies to drug 6. Malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. fMRI signal change, IGT results at baseline, days 14 after treatment 2. Visual Analogue Scale (VAS), measured at baseline, days1, 2, 3,7,14 after treatment 3. Flare pain per day during days 3, 7, 14 after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. SF-36 at baseline, days 14 after treatment 2. Dosage of rescue drug (Oxycodone) consumed per day at days3, 7, and 14 after treatment 3. Presence, frequency and duration of adverse effects at 7, 14 days | — |
Countries
China
Outcome results
None listed