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A comparison of high rate, low tidal volume ventilation and conventional ventilation in the management of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN55387780
Enrollment
Unknown
Registered
2004-09-30
Start date
2002-11-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress Respiratory Injury of other and unspecified intrathoracic organs

Interventions

Randomised controlled trial. Random allocation to: 1. New Treatment - high respiratory rate, low tidal volume ventilation 2. Standard Treatment - conventional ventilation 13/09/2012: Please note that

Sponsors

Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients intubated and receiving mechanical ventilation who have an acute decrease in ratio of partial pressure of arterial oxygen to fraction of inspired oxygen reaching the criteria for ALI and ARDS set by the American-European consensus conference committee

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

MeasureTime frame
1. Ventilator free days in first 28 days 2. Reduced production of IL-6, IL-8 IL-10 Neutrophil count and tumour necrosis factor (TNF) in response to ventilation—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026