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A pragmatic randomised controlled trial in primary care to determine the effectiveness of active physiotherapy treatment and enhanced pharmacy review for knee pain

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN55376150
Enrollment
325
Registered
2003-01-03
Start date
2001-05-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee pain Musculoskeletal Diseases Knee pain

Interventions

1. Pharmacy review of medication 2. Active physiotherapy management 3. Advice leaflet

Sponsors

Arthritis Research Campaign (ARC) (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Male and female patients aged 55 years and above 2. Pain with or without stiffness in one or both knees 3. Considered suitable for primary care management by GP 4. Able to read English 5. Available for telephone contact 6. Able and willing to consent to participation

Exclusion criteria

Exclusion criteria: 1. Patients with potentially serious pathology (e.g. inflammatory arthritis, malignancy) on the basis of GP diagnosis or past medical history 2. Patients with severe disability: WOMAC Physical Function score ³ 40 3. Patients already on a surgical waiting list 4. Patients who have already had an exercise programme for their knee problem within the previous 3 months (normal recreational involvement in sport or exercise will not be an exclusion) 5. Patients who have received an intra-articular injection to the knee in the last 6 months 6. Patients who have a knee replacement 7. Patients unable or unwilling to receive the study interventions, or for whom the interventions are contraindicated 8. Patients with acute trauma 9. Knee pain due to malignancies

Design outcomes

Primary

MeasureTime frame
Change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 6 months.

Secondary

MeasureTime frame
Anxiety and Depression (HADS); Confidence in managing pain, function, and other symptoms associated with arthritis (Arthritis Self-Efficacy Scale); Overall health status (EuroQoL).

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 8, 2026