Acute organophosphate self-poisoning Injury, Occupational Diseases, Poisoning Organophosphate poisoning
Conditions
Interventions
Atropine and pralidoxime chloride (2 g stat followed by 500 mg/h for up to seven days) versus atropine and saline placebo.
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients (aged 14 years of above, either sex) presenting with history and signs of acute organophosphate self-poisoning in selected Sri Lankan hospitals, requiring atropine.
Exclusion criteria
Exclusion criteria: We hope to recruit all patients admitted to the medical wards with a history of acute poisoning and symptoms and signs of organophosphate poisoning, except for those: 1. Under the age of 14 years 2. Known to be pregnant 3. Have previously received Pralidoxime 4. Patients under the age of 16 or unconscious, who are present without relatives
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality at hospital discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentage of patients requiring intubation 2. Time requiring ventilation 3. Percentage of patients developing the intermediate syndrome (cranial nerve palsies and/or proximal weakness, without distal weakness, after resolution of the cholinergic crisis) | — |
Countries
Sri Lanka
Outcome results
None listed