Aquaporines, cell migration and inflammation Respiratory Adult respiratory distress syndrome
Conditions
Interventions
The following analyses will be performed on each participant:
1. Deoxyribonucleic acid (DNA) extraction from rest material of the routine diagnostic, e.g., saliva, urine or blood
2. Identification of
Sponsors
German Research Council (Deutsche Forschungsgemeinschaft [DFG]) (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Acute respiratory distress syndrome: 1.1. Timing: acute onset 1.2. Oxygenation: partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2) ratio less than 200 mmHg (regardless of positive end expiratory pressure [PEEP]) 1.3. Chest radiograph: bilateral infiltrates seen on frontal chest radiograph 1.4. Pulmonary artery wedge (PAW): less than 18 mmHg when measured or no clinical evidence of left atrial hypertension 2. Lung function testing with body plethysmography-revealed bronchial asthma 3. Patients with severe sepsis 4. Aged 18 to 70 years, both genders
Exclusion criteria
Exclusion criteria: No written informed consent is obtained
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of SNPs wthin the Aqquaporin 1 and 5 gen which contribute to the phenotypic variability of ARDS, sepsis and bronchial asthma, measured at 30 day survival and 100 day survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of survival, disease course and rehabilitation, measured at 30 day survival and 100 day survival | — |
Countries
Germany
Outcome results
None listed