Micronutrient status in adolescent girls, breakfast cereal consumption Nutritional, Metabolic, Endocrine
Conditions
Interventions
Girls are randomised to receive a daily intake of either fortified or unfortified cereal (50 g) with semi-skimmed milk (150 ml) for 12 weeks. Half of the girls are instructed to consume their cereal a
Sponsors
University of Sheffield (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female 2. Aged between 16 and 19 years 3. Skips breakfast on a regular basis 4. Healthy 5. Screening riboflavin status as measured by the erythrocyte glutathione reductase coefficient assay (EGRAC) of >1.4 and a haemoglobin level between 11.5 and 13.7g/L
Exclusion criteria
Exclusion criteria: 1. Blood donation within the last 3 months 2. Taking multivitamin or iron supplements 3. Pregnant or breastfeeding 4. Allergic to wheat, barley or milk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dietary intake: the 4-day diet diaries will be used to assess changes in micronutrient intakes and dietary patterns during the study. Nutritional status: the following biomarkers of micronutrient status will be measured at baseline and midway at 6 weeks: 1. Riboflavin status, as the erythrocyte glutathione reductase activation coefficient 2. Folate status, as plasma 5-methyltetrahydrofolate (5-MeTHF) 3. Vitamin B-12 status as plasma holotranscobalamin 4. Vitamin D status as plasma 25-OH vitamin D 5. Full blood count, including haemoglobin (Hb), packed cell volume (PCV), mean cell volume (MCV), mean cell haemoglobin (MCH) and red blood cell numbers 6. Plasma ferritin | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Height and weight are measured at the beginning and end of the study to calculate BMI measured at baseline and at the end (12 weeks) 2. Modulating effect of the time of consumption of cereal will also be examined by looking at the data from the point of view of timing of the cereal consumption | — |
Countries
United Kingdom
Outcome results
None listed