Severe acute malnutrition (SAM) in children Nutritional, Metabolic, Endocrine Severe acute malnutrition (SAM)
Conditions
Interventions
There was no experimental intervention. All study participants received in-patient treatment for complicated severe acute malnutrition according to standard protocols based on international guidelines
Sponsors
University of Copenhagen (Denmark)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children between 6 - 59 months of age 2. Admitted to Mwanamugimu Nutrition Unit paediatric wards with either: 2.1 Weight for height (W/H) below the -3 standard deviations (SD) and mid upper arm circumference (MUAC) below the cut-off points for SAM 2.2. Pitting oedema developing from both feet 3. Living near the study centre
Exclusion criteria
Exclusion criteria: 1. Children with shock, severe respiratory difficulty or significant bleeding at the time of admission 2. Weight below 4.5 kg at admission 3. Very severe anaemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma phosphate was measured at five time points: on admission, the second day of treatment, the start of the transition to F-100, day two of transition and at discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Blood essential fatty acids at admission, transition, discharge, 8 weeks, 16 weeks 2. Physical activity using accelerometers at discharge 3. Child development using the Malawi Development assessment tool at admission, transition, discharge, 8 weeks, 16 weeks 4. Thymus size using ultrasound at admission, discharge and week 8) 5. T-cell subsets and cytokines using flow cytometry at admission and discharge 6. Gut permeability (LM-test) at admission and discharge 7. Gut flora and pathogens at admission and discharge 8. Myocardial function and biomarkers at admission and discharge 9. Mortality during admission | — |
Countries
Uganda
Outcome results
None listed