Age-related macular degeneration (AMD) Eye Diseases Degeneration of macula
Conditions
Interventions
All participants asked to take daily macular pigment supplement with food, ?Macuvite? (Springfield®), consisting of 18mg lutein (in its free form) and 2.4mg zeaxanthin (derived from marigold flowers a
Sponsors
Guy's & St Thomas' NHS Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy female volunteers, aged 16-50 2. Twin pairs enrolled on TwinsUK adult registry held at St Thomas? Hospital London (aim to recruit 80 monozygotic and 80 dizygotic pairs)
Exclusion criteria
Exclusion criteria: 1. Ocular pathology 2. Gastrointestinal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heritability of response to macular pigment supplement, measured using: 1. Reverse phase high performance liquid chromatography to measure serum carotenoid levels at baseline and three months 2. Heterochromatic flicker photometry (HFP) and 2-wavelength fundus autofluorescence (AF) to measure macular pigment optical density (MPOD) at baseline, three months and six months 3. Maximum likelihood modelling using Mx programme to estimate heritability of MP response to supplementation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Relationship between central retinal thickness and MPOD, measured using: 1.1. Optical coherence tomography to measure retinal thickness 1.2. HFP and AF to measure MPOD 2. Heritability of MP in the healthy eye, measured using: 2.1. HFP and AF to measure MPOD 2.2. Maximum likelihood modelling using Mx programme to estimate heritability of MPOD | — |
Countries
United Kingdom
Outcome results
None listed