Mild cognitive impairment Mental and Behavioural Disorders Cognitive disorder
Conditions
Interventions
Comparing the results of participants on three months of estradiol versus three months on placebo.
Sponsors
Institute for the Study of Aging (USA)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male with mild cognitive impairment (Mini-Mental State Examination [MMSE] of 26 to 30) 2. Between the ages of 55 to 98 3. Hypertension was well controlled 4. Had a caregiver
Exclusion criteria
Exclusion criteria: 1. Carcinoma of the prostate, hypercalcaemia, metabolic diseases, severe Chronic Obstuctive Pulmonary Disease (COPD) and renal insufficiency 2. Clotting abnormality, hyper-coagulable states, sleep apnoea 3. Patients on coumadin with Deep Vein Thrombosis (DVT) (or with a known clotting disorder) and diabetes (if uncontrolled) 4. Liver disease, unstable coronary artery disease, history of cerebrovascular accident, recent classical migraines, thrombophlebitis or thromboembolic disease 5. Must not be on any other cognitive enhancing treatment. If so, must be washed-out for 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Mini-Mental Status Exam (MMSE) 2. Alzheimer's Disease Assessment Scale (ADAS) 3. Neuropsychatric Inventory (NPI) 4. Clinicial impression based on interview (CIBIC) | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood test results. | — |
Countries
United States of America
Outcome results
None listed